1884. Pancoast carried out the first successful insemination with donor’s sperm in Filadelfia.

1958. Gemzell published first successful results in the induction of ovulation using human gonadotropin,
           after achieving the first pregnancy.

1968. McLaren achieved the first In Vitro Fecundation (IVF) of a mouse’s egg.1965 Edwars was able to fertilize
           human eggs.

1978. Edwars and Steptoe described the IVF (In Vitro Fertilization) and embryo transfer technique, afterwards
           Louis Brown was born.

1982. 1st birth in Spain (Barcelona), obtained by in vitro fertilization.

1989. Handyside and collaborators (London), successfully used the Pre-implantation Genetic Diagnosis (PGD)
           to detect hereditary diseases

1992. Palermo and collaborators published first results of births by means of ICSI (Intracytoplasmic Sperm
           Injection) in Brussels.

2002. Kuwayama (Japan) First pregnancy from vitrified ovules.

ACT.   Over the last few years, vitrification has become established as a cryopreservation technique for both
           eggs and embryos.